Cell Chemical Biology

Receptor-ubiquitination-targeting antibody-drug conjugates for enhanced endocytosis and lysosomal deliver

Author: Zhuang, Xinlei; Lin, Li; Li, Jingchao; Yu, Gang; Chen, Bin; Xu, Yingchun; Chen, Shuqing; Yi, Wen; Pan, Liqiang

Journal: CELL CHEMICAL BIOLOGY. 2026; Vol. 33, Issue 4, pp. 506-522. DOI: 10.1016/j.chembiol.2026.02.015

Selective degradation of TBK1 uncovers mechanistic insights into blocking ccRCC progressio

Author: Liao, Chengheng; Lyu, Siying; Johnson, Rebecca L.; Shang, Tiantian; Wang, Xiaoyu; Gildor, Nina; Li, Shina; Williams, Noelle S.; James, Lindsey I.; Hu, Lianxin; Zhang, Qing

Journal: CELL CHEMICAL BIOLOGY. 2026; Vol. 33, Issue 4, pp. 461-473. DOI: 10.1016/j.chembiol.2026.03.013

Lysosome-targeting chimeras enable targeted protein degradatio

Author: Li, Bozhao; Li, Yanyan; Zhang, Jian; Badama, Siren; Zhao, Xian; Wang, Liping; Zhang, Tian; Wang, Xueting; Yi, Xiaoqing; Ding, Guo-Bin; Wang, Xudong; Nie, Guangjun

Journal: CELL CHEMICAL BIOLOGY. 2026; Vol. 33, Issue 4, pp. 433-460. DOI: 10.1016/j.chembiol.2026.01.008

A nature-inspired nanoplatform for multi-protein targeted degradation via the autophagy-lysosome pathwa

Author: Tong, Bide; Wang, Yulei; Wei, Junyu; Ou, Zixuan; Liang, Huaizhen; Lei, Jie; Zhu, Dingchao; Xu, Hanpeng; Tan, Lei; Liao, Zhiwei; Yang, Cao

Journal: CELL CHEMICAL BIOLOGY. 2026; Vol. 33, Issue 4, pp. 523-537. DOI: 10.1016/j.chembiol.2026.03.007

Law-NQO1 redox boosts the pentose phosphate pathway to confer stem-like properties and antitumor durability in effector CD8+ T cell

Author: Pang, Jianfeng; Wang, Zengge; Yang, Cuixia; Huang, Lin; Qiu, Yiran; Wang, Hui; Huang, Keling; Li, Xiaoxue; Yang, Zifeng; Pan, Hudan; Liu, Liang; Tong, Xuemei; Li, Bin; Zhang, Mingjun; Zhong, Lin; Li, Zhigang; Wang, Feng

Journal: CELL CHEMICAL BIOLOGY. 2026; Vol. 33, Issue 3, pp. 321-337. DOI: 10.1016/j.chembiol.2026.02.001

Mechanosensation promotes broad-spectrum antiviral defense through membrane remodelin

Author: Huang, Yuehan; Guo, Haoran; Gao, Delong; Tang, Yubin; Yang, Jiaxin; Ni, Fushun; Xue, Ling; Li, Huili; Liu, Dongxue; Zhang, Lili; Yang, Qingran; Wang, Shijin; Yu, Xiao-Fang; Yu, Zhenglei; Niu, Junqi; Wei, Wei

Journal: CELL CHEMICAL BIOLOGY. 2026; Vol. 33, Issue 3, pp. 307-320. DOI: 10.1016/j.chembiol.2026.01.004

Discovery of MARK2 as a physiological kinase for PER2 in the mammalian cloc

Author: Liu, Yuxiang; Li, Yang; Yu, Tenghui; V. Wang, Tao; Cui, Yunfeng; Zhu, Chen; Jia, Xiaobo; Li, Chenggang; Shen, Yuxin; Wang, Zhun; Liu, Shangchen; Huang, Juan; Rao, Yi

Journal: CELL CHEMICAL BIOLOGY. 2026; Vol. 33, Issue 3, pp. 379-395. DOI: 10.1016/j.chembiol.2026.02.007

Aerobic glycolysis promotes NLRP3 inflammasome activation via NLRP3 lactylatio

Author: Liu, Wei; Zhang, Tianyi; Wang, Bohong; Yin, Hang

Journal: CELL CHEMICAL BIOLOGY. 2026; Vol. 33, Issue 2, pp. -. DOI: 10.1016/j.chembiol.2026.01.003

Exporter Mdr1 as an importer is an achilles' heel for combating drug-resistant Candid

Author: Chen, Jinyao; Zhang, Ming; Wang, Yeji; Xie, Zhiyu; Yang, Fei; Yu, Hongjun; Zhang, Di; Fang, Min; Luan, Xiaoyi; Jin, Xueyang; Wang, Xue; Qiao, Yanan; Zheng, Shicun; Li, Xiuyun; Chang, Wenqiang; Lou, Hongxiang

Journal: CELL CHEMICAL BIOLOGY. 2026; Vol. 33, Issue 2, pp. -. DOI: 10.1016/j.chembiol.2026.01.009

Deciphering phosphorylation TACtics: Advances in phosphorylation targeting strategies and bifunctional modalitie

Author: Ke, Dong-Ting; Zhan, Zilong; Zhang, Wenliang; Hu, Zhenyi; Chen, Po-Han

Journal: CELL CHEMICAL BIOLOGY. 2026; Vol. 33, Issue 2, pp. 153-168. DOI: 10.1016/j.chembiol.2025.12.012

Homolog-Selective Degradation as a Strategy to Probe the Function of CDK6 in AML

引用次数：48

Quantitative, Wide-Spectrum Kinase Profiling in Live Cells for Assessing the Effect of Cellular ATP on Target Engagement

引用次数：30

Repurposing High-Throughput Image Assays Enables Biological Activity Prediction for Drug Discovery

引用次数：22

Recent Advances in Selective and Irreversible Covalent Ligand Development and Validation

引用次数：21

The Rheumatoid Arthritis-Associated Citrullinome

引用次数：19

Bile Acid 7 alpha-Dehydroxylating Gut Bacteria Secrete Antibiotics that Inhibit Clostridium difficile: Role of Secondary Bile Acids

引用次数：19

From Discovery to Bedside: Targeting the Ubiquitin System

引用次数：17

The Bump-and-Hole Tactic: Expanding the Scope of Chemical Genetics

引用次数：15

Chemical Induction of Aminoglycoside Uptake Overcomes Antibiotic Tolerance and Resistance in Staphylococcus aureus

引用次数：14

The Hairpin Form of r(G(4)C(2))(exp) in c9ALS/FTD Is Repeat-Associated Non-ATG Translated and a Target for Bioactive Small Molecules

引用次数：13